ZFAT plays critical roles in peripheral T cell homeostasis and its T cell receptor-mediated response

Keiko Doi, Takahiro Fujimoto, Tadashi Okamura, Masahiro Ogawa, Yoko Tanaka, Yasumasa Mototani, Motohito Goto, Takeharu Ota, Hiroshi Matsuzaki, Masahide Kuroki, Toshiyuki Tsunoda, Takehiko Sasazuki, Senji Shirasawa

研究成果: ジャーナルへの寄稿学術誌査読

15 被引用数 (Scopus)

抄録

ZFAT, originally identified as a candidate susceptibility gene for autoimmune thyroid disease, has been reported to be involved in apoptosis, development and primitive hematopoiesis. Zfat is highly expressed in T- and B-cells in the lymphoid tissues, however, its physiological function in the immune system remains totally unknown. Here, we generated the T cell-specific Zfat-deficient mice and demonstrated that Zfat-deficiency leads to a remarkable reduction in the number of the peripheral T cells. Intriguingly, a reduced expression of IL-7Rα and the impaired responsiveness to IL-7 for the survival were observed in the Zfat-deficient T cells. Furthermore, a severe defect in proliferation and increased apoptosis in the Zfat-deficient T cells following T cell receptor (TCR) stimulation was observed with a reduced IL-2Rα expression as well as a reduced IL-2 production. Thus, our findings reveal that Zfat is a critical regulator in peripheral T cell homeostasis and its TCR-mediated response.

本文言語英語
ページ(範囲)107-112
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
425
1
DOI
出版ステータス出版済み - 8月 17 2012
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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