TY - JOUR
T1 - Xanthone derivatives as potential inhibitors of miRNA processing by human Dicer
T2 - Targeting secondary structures of pre-miRNA by small molecules
AU - Murata, Asako
AU - Fukuzumi, Takeo
AU - Umemoto, Shiori
AU - Nakatani, Kazuhiko
N1 - Funding Information:
This work was supported by the Advanced research for medical products Mining Programme of the National Institute of Biomedical Innovation (NIBIO, 10–22) for K.N., and Grant-in-Aid for Young Scientists (B) for A.M. We also thank Dr. N. Taniguchi and Dr. M. Sano of RIKEN Institute, and Professor A. Yamaguchi and Dr. T. Nishi for access to their LAS-3000 instruments.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - In recent years, various biological processes have been found to be regulated by miRNA-mediated gene silencing. A small molecule that modulate the miRNA pathway will provide the biological tool for elucidating mechanisms of miRNA-mediated gene regulation, and can be the drug lead for miRNA related diseases. In this study, we demonstrated that an aminoalkoxy-substituted thioxanthone derivative interferes Dicer-mediated processing of pre-miRNA. Information about the interaction between these xanthone derivatives and pre-miRNAs will enable us to design and develop new small molecule-based inhibitors for miRNA pathway.
AB - In recent years, various biological processes have been found to be regulated by miRNA-mediated gene silencing. A small molecule that modulate the miRNA pathway will provide the biological tool for elucidating mechanisms of miRNA-mediated gene regulation, and can be the drug lead for miRNA related diseases. In this study, we demonstrated that an aminoalkoxy-substituted thioxanthone derivative interferes Dicer-mediated processing of pre-miRNA. Information about the interaction between these xanthone derivatives and pre-miRNAs will enable us to design and develop new small molecule-based inhibitors for miRNA pathway.
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U2 - 10.1016/j.bmcl.2012.10.108
DO - 10.1016/j.bmcl.2012.10.108
M3 - Article
C2 - 23164709
AN - SCOPUS:84871027932
SN - 0960-894X
VL - 23
SP - 252
EP - 255
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 1
ER -