X-ray crystal structure of Escherichia coli HspQ, a protein involved in the retardation of replication initiation

Yoshito Abe; Seijiro Shioi; Shunsuke Kita; Hikaru Nakata; Katsumi Maenaka; Daisuke Kohda; Tsutomu Katayama; Tadashi Ueda

doi:10.1002/1873-3468.12892

X-ray crystal structure of Escherichia coli HspQ, a protein involved in the retardation of replication initiation

Yoshito Abe
, Seijiro Shioi
, Shunsuke Kita
, Hikaru Nakata
, Katsumi Maenaka
, Daisuke Kohda
, Tsutomu Katayama
, Tadashi Ueda

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

4 被引用数 (Scopus)

抄録

The heat shock protein HspQ (YccV) of Escherichia coli has been proposed to participate in the retardation of replication initiation in cells with the dnaA508 allele. In this study, we have determined the 2.5-Å-resolution X-ray structure of the trimer of HspQ, which is also the first structure of a member of the YccV superfamily. The acidic character of the HspQ trimer suggests an interaction surface with basic proteins. From these results, we discuss the cellular function of HspQ, including its relationship with the DnaA508 protein.

本文言語	英語
ページ（範囲）	3805-3816
ページ数	12
ジャーナル	FEBS Letters
巻	591
号	22
DOI	https://doi.org/10.1002/1873-3468.12892
出版ステータス	出版済み - 11月 2017

!!!All Science Journal Classification (ASJC) codes

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

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title = "X-ray crystal structure of Escherichia coli HspQ, a protein involved in the retardation of replication initiation",

abstract = "The heat shock protein HspQ (YccV) of Escherichia coli has been proposed to participate in the retardation of replication initiation in cells with the dnaA508 allele. In this study, we have determined the 2.5-{\AA}-resolution X-ray structure of the trimer of HspQ, which is also the first structure of a member of the YccV superfamily. The acidic character of the HspQ trimer suggests an interaction surface with basic proteins. From these results, we discuss the cellular function of HspQ, including its relationship with the DnaA508 protein.",

author = "Yoshito Abe and Seijiro Shioi and Shunsuke Kita and Hikaru Nakata and Katsumi Maenaka and Daisuke Kohda and Tsutomu Katayama and Tadashi Ueda",

note = "Publisher Copyright: {\textcopyright} 2017 Federation of European Biochemical Societies",

year = "2017",

month = nov,

doi = "10.1002/1873-3468.12892",

language = "English",

volume = "591",

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T1 - X-ray crystal structure of Escherichia coli HspQ, a protein involved in the retardation of replication initiation

AU - Abe, Yoshito

AU - Shioi, Seijiro

AU - Kita, Shunsuke

AU - Nakata, Hikaru

AU - Maenaka, Katsumi

AU - Kohda, Daisuke

AU - Katayama, Tsutomu

AU - Ueda, Tadashi

PY - 2017/11

Y1 - 2017/11

N2 - The heat shock protein HspQ (YccV) of Escherichia coli has been proposed to participate in the retardation of replication initiation in cells with the dnaA508 allele. In this study, we have determined the 2.5-Å-resolution X-ray structure of the trimer of HspQ, which is also the first structure of a member of the YccV superfamily. The acidic character of the HspQ trimer suggests an interaction surface with basic proteins. From these results, we discuss the cellular function of HspQ, including its relationship with the DnaA508 protein.

AB - The heat shock protein HspQ (YccV) of Escherichia coli has been proposed to participate in the retardation of replication initiation in cells with the dnaA508 allele. In this study, we have determined the 2.5-Å-resolution X-ray structure of the trimer of HspQ, which is also the first structure of a member of the YccV superfamily. The acidic character of the HspQ trimer suggests an interaction surface with basic proteins. From these results, we discuss the cellular function of HspQ, including its relationship with the DnaA508 protein.

UR - https://www.scopus.com/pages/publications/85033668348

UR - https://www.scopus.com/pages/publications/85033668348#tab=citedBy

U2 - 10.1002/1873-3468.12892

DO - 10.1002/1873-3468.12892

M3 - Article

C2 - 29083032

AN - SCOPUS:85033668348

SN - 0014-5793

VL - 591

SP - 3805

EP - 3816

JO - FEBS Letters

JF - FEBS Letters

IS - 22

ER -

X-ray crystal structure of Escherichia coli HspQ, a protein involved in the retardation of replication initiation

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!!!All Science Journal Classification (ASJC) codes

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