Vitamin D₃ analogues improve cafe au lait spots in patients with von Recklinghausen's disease: Experimental and clinical studies

Topical application of vitamin D₃ analogues for 6 months was found to be effective in improving the pigmentation of cafe au lait spots in patients with yon Recklinghausen's disease. Treatment of q au lait spots grafted onto nude mice with a vitamin D₃ analogue caused suppression of bromodeoxyuridine uptake in the cells of the basal layer. Vitamin D₃ analogues also decreased melanin pigment in cafe au lait spots after 4 weeks of treatment. Thus, it is considered that long-term application of vitamin D₃ analogues is effective both for improving the pigmentation of cafe au lait spots and suppressing the development of neurofibromas in patients with von Recklinghausen's disease.