Use of c-fos functional mapping to identify the central baroreceptor reflex pathway: Advantages and limitations

R. A.L. Dampney, Y. W. Li, Y. Hirooka, P. Potts, J. W. Polson

研究成果: ジャーナルへの寄稿学術誌査読

69 被引用数 (Scopus)

抄録

Prolonged stimulation of many neurons results in the expression of the immediate early gene c-fos which in turn cause the production of the protein Fos, whose presence in a cell can be detected by immunocytochemistry. This method has been used in both conscious and anaesthetized animals to identify central neurons involved in the baroreceptor reflex. In this paper we review the factors that can influence c-fos expression, with particular emphasis on the effects of different anaesthetic agents. We conclude that the c-fos method of functional mapping, when applied carefully and critically, is a very useful method of identifying central neurons that are activated by cardiovascular stimuli in conscious animals. Anaesthetic agents can significantly alter c-fos expression, and this effect differs greatly according to the type of anaesthetic used.

本文言語英語
ページ(範囲)197-208
ページ数12
ジャーナルClinical and Experimental Hypertension
17
1-2
DOI
出版ステータス出版済み - 1995
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 内科学
  • 生理学

フィンガープリント

「Use of c-fos functional mapping to identify the central baroreceptor reflex pathway: Advantages and limitations」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル