TY - JOUR
T1 - Unrelated Cord Blood Transplantation for Severe Aplastic Anemia
AU - Yoshimi, Ayami
AU - Kojima, Seiji
AU - Taniguchi, Shuichi
AU - Hara, Junichi
AU - Matsui, Toshimitsu
AU - Takahashi, Yoshiyuki
AU - Azuma, Hiroshi
AU - Kato, Koji
AU - Nagamura-Inoue, Tokiko
AU - Kai, Shunro
AU - Kato, Shunichi
N1 - Funding Information:
This work was supported by a Research Grant for Tissue Engineering (H17-014) from the Japanese Ministry of Health, Labor, and Welfare. The authors would like to thank all of the staff members of the collaborating institutes of the Japan Cord Blood Bank Network for taking care of and reporting information on the patients. We would also like to thank Dr. Yoshiko Atsuta for the statistical analysis support.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2008/9
Y1 - 2008/9
N2 - In the present study we evaluated the feasibility of unrelated cord blood transplantation (UCBT) in patients with severe aplastic anemia (SAA). The outcome of 31 SAA patients (median age 28; range: 0.9-72.3 years old) who received UCBT was analyzed. The cumulative incidences of the neutrophil and platelet recovery after UCBT were 54.8 and 72.2%, respectively (95% confidence interval [CI] = 36.0%-70.3% and 51.3%-85.3%, respectively). The cumulative incidences of grade ≥II acute and chronic graft-versus-host disease (aGVHD, cGVHD) were 17.1% (95% CI = 6.2%-32.8%) and 19.7% (95% CI = 6.2%-38.8%), respectively. Currently, 13 patients are alive, having survived for 33.7 months (median; range: 6-77 months) after UCBT. The probability of overall survival (OS) at 2 years was 41.1% (95% CI = 23.8%-57.7%). A conditioning regimen that included low-dose total body irradiation (TBI) (2-5 Gy), fludarabine, and cyclophosphamide resulted in a favorable OS (80%; 95% CI = 20.4%-96.9%). This result suggests that UCBT using the optimal conditioning regimen can be a salvage treatment for patients without a suitable bone marrow donor and warrants evaluation in further prospective studies.
AB - In the present study we evaluated the feasibility of unrelated cord blood transplantation (UCBT) in patients with severe aplastic anemia (SAA). The outcome of 31 SAA patients (median age 28; range: 0.9-72.3 years old) who received UCBT was analyzed. The cumulative incidences of the neutrophil and platelet recovery after UCBT were 54.8 and 72.2%, respectively (95% confidence interval [CI] = 36.0%-70.3% and 51.3%-85.3%, respectively). The cumulative incidences of grade ≥II acute and chronic graft-versus-host disease (aGVHD, cGVHD) were 17.1% (95% CI = 6.2%-32.8%) and 19.7% (95% CI = 6.2%-38.8%), respectively. Currently, 13 patients are alive, having survived for 33.7 months (median; range: 6-77 months) after UCBT. The probability of overall survival (OS) at 2 years was 41.1% (95% CI = 23.8%-57.7%). A conditioning regimen that included low-dose total body irradiation (TBI) (2-5 Gy), fludarabine, and cyclophosphamide resulted in a favorable OS (80%; 95% CI = 20.4%-96.9%). This result suggests that UCBT using the optimal conditioning regimen can be a salvage treatment for patients without a suitable bone marrow donor and warrants evaluation in further prospective studies.
UR - https://www.scopus.com/pages/publications/49449104128
UR - https://www.scopus.com/pages/publications/49449104128#tab=citedBy
U2 - 10.1016/j.bbmt.2008.07.003
DO - 10.1016/j.bbmt.2008.07.003
M3 - Article
C2 - 18721769
AN - SCOPUS:49449104128
SN - 1083-8791
VL - 14
SP - 1057
EP - 1063
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 9
ER -