Ultrasonic implantation of calcium metasilicate glass particles into PMMA

K. Tsuru, S. Hayakawa, C. Ohtsuki, A. Osaka

研究成果: ジャーナルへの寄稿学術誌査読

14 被引用数 (Scopus)


Polymer materials for clinical applications should be bioactive and have a bone-bonding ability. In order to provide poly(methyl methacrylate) (PMMA) with bioactivity, granules ( < 45 μm) of a bioactive glass 50CaO.50SiO2 (mol %) were implanted into PMMA: they were suspended together with a piece of PMMA in a 40 tetrahydrofuran-60 ethanol (vol %) solution and ultrasonically agitated. The granules of < 10 μm in size were impregnated at ~ 40-20 μm depth below the substrate surface. Two types were detected on the PMMA surface: (a) a glass-granule layer on PMMA, and (b) an inner granule layer, a PMMA layer, and an outer granule layer on the PMMA. The bioactivity of the implanted PMMA substrates was examined in vitro with a simulated body fluid (Kokubo solution). Apatite was precipitated on all glass granules and the whole substrate surfaces within 1 d. After 4 h soaking in the Kokubo solution, aggregates of apatite particles appeared on the substrate surface, independently of those on the glass granules, and they grew and proliferated on the whole subtrate surface in 7 d. Silica gel islands on PMMA due to the silicate anions from the glass were considered to induce nucleation of the apatite particles.

ジャーナルJournal of Materials Science: Materials in Medicine
出版ステータス出版済み - 8月 1998

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • バイオエンジニアリング
  • 生体材料
  • 生体医工学


「Ultrasonic implantation of calcium metasilicate glass particles into PMMA」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。