TY - JOUR
T1 - Triterpenoid saponins from Hydrocotyle bonariensis Lam
AU - Tabopda, Turibio Kuiate
AU - Mitaine-Offer, Anne Claire
AU - Miyamoto, Tomofumi
AU - Tanaka, Chiaki
AU - Mirjolet, Jean Franois
AU - Duchamp, Olivier
AU - Ngadjui, Bonaventure Tchaleu
AU - Lacaille-Dubois, Marie Aleth
N1 - Funding Information:
The authors are grateful to the “Conseil Régional de Bourgogne” for financial support.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/1
Y1 - 2012/1
N2 - Phytochemical investigation of the under-ground parts of Hydrocotyle bonariensis led to the isolation of five oleanane-type triterpenoid saponins, 3-O-{β-d-glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-21-O-(2-methylbutyroyl)-22-O-acetyl-R 1-barrigenol, 3-O-{β-d-glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-21-O- (2-methylbutyroyl)-28-O-acetyl-R 1-barrigenol, 3-O-{β-d- glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-21-O-acetyl-R 1-barrigenol, 3-O-{β-d-glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-R 1-barrigenol, and 3-O-{β-d-glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-22-O-(2-methylbutyroyl)-A 1- barrigenol, together with the known saniculoside-R1. Their structures were established by 2D NMR techniques and mass spectrometry. Six compounds were evaluated against two human colon cancer cell lines, HCT 116 and HT-29. Two compounds showed weak cytotoxicity with IC 50 24.1 and 24.0, 83.0 and 83.6 μM against HT-29 and HCT 116, respectively.
AB - Phytochemical investigation of the under-ground parts of Hydrocotyle bonariensis led to the isolation of five oleanane-type triterpenoid saponins, 3-O-{β-d-glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-21-O-(2-methylbutyroyl)-22-O-acetyl-R 1-barrigenol, 3-O-{β-d-glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-21-O- (2-methylbutyroyl)-28-O-acetyl-R 1-barrigenol, 3-O-{β-d- glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-21-O-acetyl-R 1-barrigenol, 3-O-{β-d-glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-R 1-barrigenol, and 3-O-{β-d-glucopyranosyl-(1 → 2)-[α-l-arabinopyranosyl-(1 → 3)]-β-d-glucuronopyranosyl}-22-O-(2-methylbutyroyl)-A 1- barrigenol, together with the known saniculoside-R1. Their structures were established by 2D NMR techniques and mass spectrometry. Six compounds were evaluated against two human colon cancer cell lines, HCT 116 and HT-29. Two compounds showed weak cytotoxicity with IC 50 24.1 and 24.0, 83.0 and 83.6 μM against HT-29 and HCT 116, respectively.
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U2 - 10.1016/j.phytochem.2011.08.027
DO - 10.1016/j.phytochem.2011.08.027
M3 - Article
C2 - 22019087
AN - SCOPUS:84655160809
SN - 0031-9422
VL - 73
SP - 142
EP - 147
JO - Phytochemistry
JF - Phytochemistry
ER -
