Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells

Junichi Ikenouchi, Mikio Furuse, Kyoko Furuse, Hiroyuki Sasaki, Sachiko Tsukita, Shoichiro Tsukita

研究成果: ジャーナルへの寄稿学術誌査読

632 被引用数 (Scopus)

抄録

For epithelia to function as barriers, the intercellular space must be sealed. Sealing two adjacent cells at bicellular tight junctions (bTJs) is well described with the discovery of the claudins. Yet, there are still barrier weak points at tricellular contacts, where three cells join together. In this study, we identify tricellulin, the first integral membrane protein that is concentrated at the vertically oriented TJ strands of tricellular contacts. When tricellulin expression was suppressed with RNA interference, the epithelial barrier was compromised, and tricellular contacts and bTJs were disorganized. These findings indicate the critical function of tricellulin for formation of the epithelial barrier.

本文言語英語
ページ(範囲)939-945
ページ数7
ジャーナルJournal of Cell Biology
171
6
DOI
出版ステータス出版済み - 12月 19 2005
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 細胞生物学

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