TY - JOUR
T1 - Trends in hepatocellular carcinoma incident cases in Japan between 1996 and 2019
AU - Nakano, Masahito
AU - Yatsuhashi, Hiroshi
AU - Bekki, Shigemune
AU - Takami, Yuko
AU - Tanaka, Yasuhito
AU - Yoshimaru, Yoko
AU - Honda, Koichi
AU - Komorizono, Yasuji
AU - Harada, Masaru
AU - Shibata, Michihiko
AU - Sakisaka, Shotaro
AU - Shakado, Satoshi
AU - Nagata, Kenji
AU - Yoshizumi, Tomoharu
AU - Itoh, Shinji
AU - Sohda, Tetsuro
AU - Oeda, Satoshi
AU - Nakao, Kazuhiko
AU - Sasaki, Ryu
AU - Yamashita, Tsutomu
AU - Ido, Akio
AU - Mawatari, Seiichi
AU - Nakamuta, Makoto
AU - Aratake, Yoshifusa
AU - Matsumoto, Shuichi
AU - Maeshiro, Tatsuji
AU - Goto, Takashi
AU - Torimura, Takuji
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - We examined the epidemiological trends, including the distribution of sex, age, and disease etiology, in HCC incident cases, over 24 years. Data of 20,547 HCC patients (1996–2019) were analyzed in this prospective study. We divided the study period into four 6-yearly quarters. HCC etiology was categorized as hepatitis B virus (HBV) infection, HBV + hepatitis C virus (HCV) infection, HCV infection, and both negative (non-BC). The incident cases of HCC per quarter of the study period were 4311 (21.0%), 5505 (26.8%), 5776 (28.1%), and 4955 (24.1%), sequentially. Overall, 14,020 (68.2%) patients were male. The number of HCC cases in patients < 60 years, 60–69 years, 70–79 years, and ≥ 80 years were 3711 (18.1%), 6652 (32.4%), 7448 (36.2%), and 2736 (13.3%), respectively. The average age of newly-diagnosed patients increased in each quarter. HCC was associated with HBV, HBV + HCV, and HCV infections and non-BC in 2997 (14.6%), 187 (0.9%), and 12,019 (58.5%), and 5344 (26.0%) cases, respectively. The number of HCV-associated cases decreased in each quarter, while that of non-BC-associated cases increased. HCC incident cases tend to increase in the elderly and in non-BC patients; in contrast, HCC incident cases due to HCV tend to decrease.
AB - We examined the epidemiological trends, including the distribution of sex, age, and disease etiology, in HCC incident cases, over 24 years. Data of 20,547 HCC patients (1996–2019) were analyzed in this prospective study. We divided the study period into four 6-yearly quarters. HCC etiology was categorized as hepatitis B virus (HBV) infection, HBV + hepatitis C virus (HCV) infection, HCV infection, and both negative (non-BC). The incident cases of HCC per quarter of the study period were 4311 (21.0%), 5505 (26.8%), 5776 (28.1%), and 4955 (24.1%), sequentially. Overall, 14,020 (68.2%) patients were male. The number of HCC cases in patients < 60 years, 60–69 years, 70–79 years, and ≥ 80 years were 3711 (18.1%), 6652 (32.4%), 7448 (36.2%), and 2736 (13.3%), respectively. The average age of newly-diagnosed patients increased in each quarter. HCC was associated with HBV, HBV + HCV, and HCV infections and non-BC in 2997 (14.6%), 187 (0.9%), and 12,019 (58.5%), and 5344 (26.0%) cases, respectively. The number of HCV-associated cases decreased in each quarter, while that of non-BC-associated cases increased. HCC incident cases tend to increase in the elderly and in non-BC patients; in contrast, HCC incident cases due to HCV tend to decrease.
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U2 - 10.1038/s41598-022-05444-z
DO - 10.1038/s41598-022-05444-z
M3 - Article
C2 - 35087153
AN - SCOPUS:85123838394
SN - 2045-2322
VL - 12
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 1517
ER -
