Transient Ca2+ entry by plasmalogen-mediated activation of receptor potential cation channel promotes AMPK activity

Masanori Honsho, Shiro Mawatari, Takehiko Fujino

研究成果: ジャーナルへの寄稿学術誌査読

4 被引用数 (Scopus)

抄録

Ethanolamine-containing alkenyl ether glycerophospholipids, plasmalogens, are major cell membrane components of mammalian cells that activate membrane protein receptors such as ion transporters and G-protein coupled receptors. However, the mechanism by which plasmalogens modulate receptor function is unknown. Here, we found that exogenously added plasmalogens activate transient receptor potential cation channel subfamily C member 4 (TRPC4) to increase Ca2+ influx, followed by calcium/calmodulin-dependent protein kinase 2-mediated phosphorylation of AMP-activated protein kinase (AMPK). Upon topical application of plasmalogens to the skin of mice, AMPK activation was observed in TRPC4-expressing hair bulbs and hair follicles. Here, TRPC4 was co-localized with the leucine-rich repeat containing G protein-coupled receptor 5, a marker of hair-follicle stem cells, leading to hair growth. Collectively, this study indicates that plasmalogens could function as gate openers for TRPC4, followed by activating AMPK, which likely accelerates hair growth in mice.

本文言語英語
論文番号1008626
ジャーナルFrontiers in Molecular Biosciences
9
DOI
出版ステータス出版済み - 11月 4 2022

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 生化学、遺伝学、分子生物学(その他)

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