Transdermal Transmission Blocking Vaccine for Malaria using a Solid-in-Oil Dispersion

研究成果: ジャーナルへの寄稿学術誌査読

抄録

Malaria is a mosquito-borne infectious disease that is widespread in developing countries. Malaria vaccines are important in efforts to eradicate malaria; however, vaccines are usually administered by injection, which requires medical personnel and has a risk of causing infection. Transdermal vaccines can be administered without damaging the skin and thus are ideal for the prevention of malaria. However, the stratum corneum forms a "brick and mortar" like structure in which stratum corneum cells are embedded in a hydrophobic matrix composed of lipids, which strongly inhibits the permeation of hydrophilic substances. In the present study, we designed a transdermal vaccine against vivax malaria using a solid-in-oil (S/O) dispersion. The S/O dispersion of a transmission blocking vaccine candidate, Pvs25 from Plasmodium vivax, showed higher skin penetration than that of the aqueous solution. Mice immunized with the S/O dispersion generated antibodies at similar titers as the mice immunized by injection, over the mid- to long-term. These results provide information for the development of transdermally administered malaria vaccines toward the eradication of malaria.

本文言語英語
ページ(範囲)411-415
ページ数5
ジャーナルJournal of Pharmaceutical Sciences
112
2
DOI
出版ステータス出版済み - 2月 2023

!!!All Science Journal Classification (ASJC) codes

  • 薬科学

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