Total synthesis of novel bioactive natural product paracaseolide A and analogues: Computational evaluation of a 'proposed' biomimetic Diels-Alder reaction

Laxmaiah Vasamsetty, Debashis Sahu, Bishwajit Ganguly, Faiz Ahmed Khan, Goverdhan Mehta

研究成果: ジャーナルへの寄稿学術誌査読

8 被引用数 (Scopus)

抄録

A short and generally applicable synthesis of bioactive tetracyclic natural product paracaseolide A has been accomplished employing a 'proposed' biomimetic Diels-Alder reaction as the key strategic step. The Diels-Alder precursors for this purpose were readily assembled through a versatile Suzuki coupling on preformed α-halo butenolides. The mechanistic aspects of the 'putative' biomimetic Diels-Alder reaction have been probed using computational methods, which suggest that this [4+2]-cycloaddition proceeds through a step-wise process and product profile is thermodynamically governed.

本文言語英語
ページ(範囲)8488-8497
ページ数10
ジャーナルTetrahedron
70
45
DOI
出版ステータス出版済み - 11月 11 2014
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 創薬
  • 有機化学

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