Topographical control of neurite extension on stripe-patterned polymer films

Akinori Tsuruma, Masaru Tanaka, Sadaaki Yamamoto, Nobuyuki Fukushima, Hiroshi Yabu, Masatsugu Shimomura

研究成果: ジャーナルへの寄稿学術誌査読

19 被引用数 (Scopus)


Controlling cell responses to material surfaces is important for tissue engineering. Topographical property on material surfaces can play a crucial role in directing nerve regeneration. We prepared regular stripe-patterned (groove-ridge pattern) polymer film by self-organization in order to control direction of neurite extension. Neural cells from cerebral cortex of embryonic day-14 mice were cultured on the film coated with poly-l-lysine. Here, we describe a complex and unusual contact guidance dependent on the pattern feature size. The neurites grew perpendicular to wide groove of 12.7 μm and wide ridge of 4.3 μm but parallel to narrow grooves (6.1 and 8.4 μm) and narrow ridge (2.2 and 3.6 μm). The neurites sprouted parallel to the narrow groove but uniformly on the wide groove. The emersion of neurites was suppressed and the length of neurites was longer compared with on a flat film. These results are of interest to understanding contact guidance and designing scaffold for neural network formation.

ジャーナルColloids and Surfaces A: Physicochemical and Engineering Aspects
出版ステータス出版済み - 8月 15 2006

!!!All Science Journal Classification (ASJC) codes

  • 表面および界面
  • 物理化学および理論化学
  • コロイド化学および表面化学


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