Thoracic endografting increases cardiac afterload and leads to left ventricular hypertrophy in dogs

Yoshiyuki Yamashita, Yasuhisa Oishi, Yuma Motomatsu, Kazuto Hirayama, Takeaki Harada, Tomoki Ushijima, Satoshi Fujita, Satoshi Kimura, Hiromichi Sonoda, Hideki Tatewaki, Yoshihisa Tanoue, Genya Sunagawa, Takuya Nishikawa, Keita Saku, Akira Shiose

研究成果: ジャーナルへの寄稿学術誌査読

7 被引用数 (Scopus)


OBJECTIVES Aortic endografting can cause aortic stiffening. We aimed to determine the chronic effect of thoracic endografting on cardiac afterload, function and remodelling. METHODS Eleven dogs were included, and all except 1 was successfully assessed [endograft, n = 5; sham operation (control), n = 5]. We deployed a stent graft in the descending aorta. The ascending aortic pressure and flow were measured, and aortic input impedance was obtained by frequency analysis to determine characteristic impedance and arterial compliance. Left ventricular pressure-volume relations were measured with an admittance catheter. Measurements were performed before, 10 min after and 3 months after endografting. Following euthanasia, we weighed the left ventricle of each dog and measured the cardiomyocyte cell size. RESULTS Arterial compliance decreased from 0.47 ± 0.07 to 0.36 ± 0.06 and to 0.31 ± 0.05 ml/mmHg (both P < 0.01 versus baseline), and characteristic impedance increased from 0.11 ± 0.04 to 0.19 ± 0.05 and to 0.21 ± 0.04 mmHg/ml/s (both P < 0.01 versus baseline) 10 min and 3 months after endografting, respectively. Pressure-volume relation analysis showed that arterial elastance increased from 5.3 ± 1.0 to 6.7 ± 1.6 (at 10 min) and to 6.8 ± 1.0 mmHg/ml (at 3 months) (both P < 0.05 versus baseline), but end-systolic elastance and ventriculo-arterial coupling remained unchanged. Left ventricular weight to body weight ratio and left ventricular cardiomyocyte cell width in the endograft group were larger compared with the control's results (5.06 ± 0.27 g/kg vs 4.20 ± 0.49 g/kg, P = 0.009, 15.1 ± 1.7 μm vs 13.9 ± 1.5 μm, P = 0.02, respectively). CONCLUSIONS The mid-term effect of the descending aortic endografting on left ventricular contractility and efficiency in canine normal hearts was minimal. However, endografting resulted in increased cardiac afterload and left ventricular hypertrophy.

ジャーナルEuropean Journal of Cardio-thoracic Surgery
出版ステータス出版済み - 4月 1 2019

!!!All Science Journal Classification (ASJC) codes

  • 外科
  • 呼吸器内科
  • 循環器および心血管医学


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