The validity of the surgical indication for intraductal papillary mucinous neoplasm of the pancreas advocated by the 2017 revised International Association of Pancreatology consensus guidelines

Yusuke Watanabe, Sho Endo, Kazuyoshi Nishihara, Keijiro Ueda, Mari Mine, Sadafumi Tamiya, Toru Nakano, Masao Tanaka

研究成果: ジャーナルへの寄稿学術誌査読

13 被引用数 (Scopus)

抄録

Purpose: This study was performed to evaluate the surgical indication for intraductal papillary mucinous neoplasm (IPMN) advocated by the 2017 revised International Association of Pancreatology consensus guidelines (IAPCG2017). Methods: The medical records of 63 patients who underwent pancreatectomy for IPMN were retrospectively reviewed. Results: Thirteen patients had main-duct IPMN, 25 had mixed IPMN, and 25 had branch-duct IPMN with frequencies of high-grade dysplasia or invasive carcinoma of 62, 24, and 28%, respectively. The sensitivity and specificity of high-risk stigmata for high-grade dysplasia or invasive carcinoma advocated by the IAPCG2017 were 90 and 67%, respectively. Of 17 patients with invasive carcinoma, all patients had high-risk stigmata, and 16 had an enhanced mural nodule (MN) of ≥ 5 mm. The sensitivity and specificity of a ≥ 5-mm enhanced MN for predicting invasive carcinoma were 94% and 87%, respectively. Conclusions: Introducing a size threshold for enhanced MNs into the assessment of high-risk stigmata increases the specificity without jeopardizing the sensitivity. The surgical indication for any type of IPMN may be determined using only a ≥ 5-mm enhanced MN. When the type of IPMN is classified strictly, about half of IPMNs are mixed type, and most are benign. The surgical indication for mixed IPMN should be reconsidered.

本文言語英語
ページ(範囲)1011-1019
ページ数9
ジャーナルSurgery today
48
11
DOI
出版ステータス出版済み - 11月 1 2018
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!!!All Science Journal Classification (ASJC) codes

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