The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities

Hiroshi Yoshikawa, Tatsuro Ishibashi, Yasuaki Hata, Hajime Inomata, Katsuo Sueishi

研究成果: ジャーナルへの寄稿学術誌査読

3 被引用数 (Scopus)

抄録

The exact mechanisms of the angiostatic effect by tecogalan sodium (TS) remain unclear. We examined the effects of TS on in vitro angiogenic activity, proteolytic activity and proliferation of retinal vascular endothelial cells (RECs). TS markedly inhibited the in vitro angiogenic activity of RECs although the growth inhibition of RECs was small. TS apparently decreased the cell-associated urokinase-type plasminogen activator (uPA) activity and matrix metalloprotease 1 (MMP-1) activity even in the presence of anti-bFGF IgG. Thus, the suppression of the periendothelial matrix-degrading activities related to uPA and MMP-1 is suggested to be another possible mechanism of the antiangiogenic effect of TS, besides its prevention of bFGF REC binding which has previously been reported. Copyright (C) 2000 S. Karger AG, Basel.

本文言語英語
ページ(範囲)261-269
ページ数9
ジャーナルOphthalmic Research
32
6
DOI
出版ステータス出版済み - 2000

!!!All Science Journal Classification (ASJC) codes

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

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