TY - JOUR
T1 - The role of nuclear Y-box binding protein 1 as a global marker in drug resistance
AU - Kuwano, Michihiko
AU - Oda, Yoshinao
AU - Izumi, Hiroto
AU - Yang, Song Ju
AU - Uchiumi, Takeshi
AU - Iwamoto, Yukihide
AU - Toi, Masakazu
AU - Fujii, Teruhiko
AU - Yamana, Hideaki
AU - Kinoshita, Hisafumi
AU - Kamura, Toshiharu
AU - Tsuneyoshi, Masazumi
AU - Yasumoto, Kosei
AU - Kohno, Kimitoshi
PY - 2004/11
Y1 - 2004/11
N2 - Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non - P-glycoprotein.
AB - Gene expression can be regulated by nuclear factors at the transcriptional level. Many such factors regulate MDR1 gene expression, but what are the sequence elements and transcription factors that control the basal and inducible expression of this gene? The general principles through which transcription factors participate in drug resistance are now beginning to be understood. Here, we review the factors involved in the transcriptional regulation of the MDR1 gene. In particular, we focus on the transcription factor Y-box binding protein 1 and discuss the possible links between Y-box binding protein 1 expression and drug resistance in cancer, which are mediated by the transmembrane P-glycoprotein or non - P-glycoprotein.
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U2 - 10.1158/1535-7163.1485.3.11
DO - 10.1158/1535-7163.1485.3.11
M3 - Short survey
C2 - 15542787
AN - SCOPUS:9444259316
SN - 1535-7163
VL - 3
SP - 1485
EP - 1492
JO - Molecular cancer therapeutics
JF - Molecular cancer therapeutics
IS - 11
ER -