The Role of Microglial Purinergic Receptors in Pain Signaling

Hidetoshi Tozaki-Saitoh, Hiroshi Takeda, Kazuhide Inoue

研究成果: ジャーナルへの寄稿学術誌査読

10 被引用数 (Scopus)

抄録

Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal and non-neuronal cells. Microglia and astrocytes express a variety of purinergic effectors, and a variety of receptors play critical roles in the pathogenesis of neuropathic pain. In this review, we discuss our current knowledge of purinergic signaling and of the compounds that modulate purinergic transmission, with the aim of highlighting the importance of purinergic pathways as targets for the treatment of persistent pain.

本文言語英語
論文番号1919
ジャーナルMolecules
27
6
DOI
出版ステータス出版済み - 3月 1 2022

!!!All Science Journal Classification (ASJC) codes

  • 分析化学
  • 化学(その他)
  • 分子医療
  • 薬科学
  • 創薬
  • 物理化学および理論化学
  • 有機化学

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