The renin-angiotensin system in acute respiratory distress syndrome

Yumiko Imai, Keiji Kuba, Josef M. Penninger

研究成果: ジャーナルへの寄稿総説査読

22 被引用数 (Scopus)

抄録

Angiotensin-converting enzyme 2 (ACE2) counterbalances with ACE and functions as a negative regulator of the renin-angiotensin system (RAS). The importance of RAS in acute respiratory distress syndrome (ARDS) has recently re-emerged owing to the identification of ACE2 as a receptor for the SARS-coronavirus. Recent studies have demonstrated that ACE2 protects mice from acute lung injury as well as SARS-mediated lung injury. We review the role of the RAS, in particular ACE2, in the pathogenesis of ARDS.

本文言語英語
ページ(範囲)225-229
ページ数5
ジャーナルDrug Discovery Today: Disease Mechanisms
3
2
DOI
出版ステータス出版済み - 2006
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 分子医療
  • 創薬

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