TY - JOUR
T1 - The pruritogenic mediator endothelin-1 shifts the dendritic cell–T-cell response toward Th17/Th1 polarization
AU - Nakahara, T.
AU - Kido-Nakahara, M.
AU - Ohno, F.
AU - Ulzii, D.
AU - Chiba, T.
AU - Tsuji, G.
AU - Furue, M.
N1 - Funding Information:
This work was partly supported by grants from The Ministry of Health, Labour and Welfare, Research on the Development of New Drugs from the Japan Agency for Medical Research and Development (AMED), and The Leading Advanced Projects for Medical Innovation (LEAP).
Funding Information:
Funding information This work was partly supported by grants from The Ministry of Health, Labour and Welfare, Research on the Development of New Drugs from the Japan Agency for Medical Research and Development (AMED), and The Leading Advanced Projects for Medical Innovation (LEAP). We would like to thank Chie Shimomura and Kei Fujishima for technical assistance.
Publisher Copyright:
© 2017 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
PY - 2018/2
Y1 - 2018/2
N2 - Endothelin-1 (ET-1) is associated with skin diseases such as atopic dermatitis (AD) and psoriasis. ET-1 is enhanced in the skin of patients AD and psoriasis. In addition, plasma levels of ET-1 are elevated in AD and psoriasis. Although both AD and psoriasis are T-cell–mediated skin diseases, the association between ET-1 and the T-cell immune response has not been clarified. To evaluate the role of ET-1 in inflammatory skin disease, we sought to investigate the effects of ET-1 on the functions of dendritic cells (DCs) and subsequent immune responses. For this purpose, we immunohistochemically confirmed the upregulation of ET-1 in the epidermis of patients with AD or psoriasis. ET-1 directly induced phenotypic maturation of bone marrow-derived DCs (BMDCs). In addition, ET-1 augmented the production of several cytokines and allogeneic stimulatory capacity of BMDCs. Interestingly, ET-1–activated BMDCs primed T cells to produce Th1 and Th17 cytokines, but not Th2 cytokines. These findings indicate that ET-1 polarizes the DC–T-cell response toward Th17/1 differentiation and may augment the persistent course of inflammatory skin diseases.
AB - Endothelin-1 (ET-1) is associated with skin diseases such as atopic dermatitis (AD) and psoriasis. ET-1 is enhanced in the skin of patients AD and psoriasis. In addition, plasma levels of ET-1 are elevated in AD and psoriasis. Although both AD and psoriasis are T-cell–mediated skin diseases, the association between ET-1 and the T-cell immune response has not been clarified. To evaluate the role of ET-1 in inflammatory skin disease, we sought to investigate the effects of ET-1 on the functions of dendritic cells (DCs) and subsequent immune responses. For this purpose, we immunohistochemically confirmed the upregulation of ET-1 in the epidermis of patients with AD or psoriasis. ET-1 directly induced phenotypic maturation of bone marrow-derived DCs (BMDCs). In addition, ET-1 augmented the production of several cytokines and allogeneic stimulatory capacity of BMDCs. Interestingly, ET-1–activated BMDCs primed T cells to produce Th1 and Th17 cytokines, but not Th2 cytokines. These findings indicate that ET-1 polarizes the DC–T-cell response toward Th17/1 differentiation and may augment the persistent course of inflammatory skin diseases.
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U2 - 10.1111/all.13322
DO - 10.1111/all.13322
M3 - Article
C2 - 28960333
AN - SCOPUS:85031117963
SN - 0105-4538
VL - 73
SP - 511
EP - 515
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
IS - 2
ER -