The primacy of octacalcium phosphate collagen composites in bone regeneration

Shinji Kamakura, Kazuo Sasaki, Takahiro Homma, Yoshitomo Honda, Takahisa Anada, Seishi Echigo, Osamu Suzuki

研究成果: ジャーナルへの寄稿学術誌査読

56 被引用数 (Scopus)


We have engineered a scaffold constructed of synthetic octacalcium phosphate (OCP) and porcine collagen sponge (OCP/Col), and reported that OCP/Col drastically enhanced bone regeneration. In this study, we investigated whether OCP/Col would enhance bone regeneration more than β-tricalcium phosphate (β-TCP) collagen composite (β-TCP/Col) or hydroxyapatite (HA) collagen composite (HA/Col). Discs of OCP/Col, β-TCP/Col, or HA/Col were implanted into critical-sized defects in rat crania and fixed at 4 or 12 weeks after implantation. The newly formed bone and the remaining granules of implants in the defect were determined by histomorphometrical analysis, and radiographic and histological examinations were performed. Statistical analysis showed that the newly formed bone by the implantation of OCP/Col was significantly more than that of β-TCP/Col or HA/Col. In contrast, the remaining granules in OCP/Col were significantly lower than those in β-TCP/Col or HA/Col. Bone regeneration by OCP/Col was based on secured calcified collagen and bone nucleation by OCP, whereas bone regeneration by β-TCP/Col or HA/Col was initiated by poorly calcified collagen and osteoconductivity by β-TCP or HA. This study showed that the implantation of OCP/Col in a rat cranial defect enhanced more bone regeneration than β-TCP/Col and HA/Col.

ジャーナルJournal of Biomedical Materials Research - Part A
出版ステータス出版済み - 11月 1 2007

!!!All Science Journal Classification (ASJC) codes

  • セラミックおよび複合材料
  • 生体材料
  • 生体医工学
  • 金属および合金


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