The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Sri Fatmawati; Taslim Ersam; Kuniyoshi Shimizu

doi:10.1016/j.phymed.2014.11.001

The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

Sri Fatmawati, Taslim Ersam, Kuniyoshi Shimizu

サスティナブル資源科学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

30 被引用数 (Scopus)

抄録

We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC₅₀ value of 11.98 μg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC₅₀ of 3.48 μM.

本文言語	英語
ページ（範囲）	49-51
ページ数	3
ジャーナル	Phytomedicine
巻	22
号	1
DOI	https://doi.org/10.1016/j.phymed.2014.11.001
出版ステータス	出版済み - 3月 2015

!!!All Science Journal Classification (ASJC) codes

分子医療
薬理学
薬科学
創薬
補完代替医療

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10.1016/j.phymed.2014.11.001

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abstract = "We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 μg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 μM.",

author = "Sri Fatmawati and Taslim Ersam and Kuniyoshi Shimizu",

note = "Funding Information: This work was supported by a grant from research project for International Research Collaboration and Scientific Publication, Directorate General of Higher Education, Ministry of Education and Culture, Indonesia. Publisher Copyright: {\textcopyright} 2014 Elsevier GmbH.",

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AU - Ersam, Taslim

AU - Shimizu, Kuniyoshi

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N2 - We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 μg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 μM.

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The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn

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!!!All Science Journal Classification (ASJC) codes

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