@article{e0e09c5561a542dcbfee4652c8bdd46d,
title = "The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors",
abstract = "During the direct reprogramming of fibroblasts to hepatocyte-like cells, Foxa3 acts as a pioneer factor, similar to Foxa1 and Foxa2, but leaves its binding site to interact and migrate with RNA polymerase II, thereby inducing the transcription of target genes.",
author = "Kenichi Horisawa and Miyako Udono and Kazuko Ueno and Yasuyuki Ohkawa and Masao Nagasaki and Sayaka Sekiya and Atsushi Suzuki",
note = "Funding Information: We thank Drs. Masafumi Onodera, Hiroshi Kimura, Toshio Kitamura, and Naoki Nariai for sharing reagents and supporting analyses, and Yuuki Honda, Chiaki Kaieda, Mizuho Oda, and Emiko Koba for excellent technical assistance. This work was supported in part by the JSPS KAKENHI (grant numbers JP16H01850, JP16K08592, JP18H05102, JP19H01177, JP19H05267, and JP20H05040), the CREST Program of AMED, the Program for Basic and Clinical Research on Hepatitis of AMED, the Practical Research Project for Rare/Intractable Diseases of AMED, the Research Center Network for Realization of Regenerative Medicine of AMED, the Cooperative Research Project Program of the Medical Institute of Bioregulation in Kyushu University, the Takeda Science Foundation, the Uehara Memorial Foundation, the Life Science Foundation of Japan, the Hitachi Global Foundation (the Kurata Grants), the Inamori Foundation, and the Mitsubishi Foundation. K.H. M.U. and S.S. performed cell-culture and biochemical experiments, collected data, and conducted data analyses. K.H. K.U. Y.O. and M.N. performed mRNA-seq, ChIP-seq, and FAIRE-seq and analyzed the data. K.H. and A.S. prepared all figures and wrote the paper. A.S. contributed to the conception, design, and overall project management. The authors declare no competing interests. Funding Information: We thank Drs. Masafumi Onodera, Hiroshi Kimura, Toshio Kitamura, and Naoki Nariai for sharing reagents and supporting analyses, and Yuuki Honda, Chiaki Kaieda, Mizuho Oda, and Emiko Koba for excellent technical assistance. This work was supported in part by the JSPS KAKENHI (grant numbers JP16H01850 , JP16K08592 , JP18H05102 , JP19H01177 , JP19H05267 , and JP20H05040 ), the CREST Program of AMED , the Program for Basic and Clinical Research on Hepatitis of AMED , the Practical Research Project for Rare/Intractable Diseases of AMED , the Research Center Network for Realization of Regenerative Medicine of AMED , the Cooperative Research Project Program of the Medical Institute of Bioregulation in Kyushu University , the Takeda Science Foundation , the Uehara Memorial Foundation , the Life Science Foundation of Japan , the Hitachi Global Foundation (the Kurata Grants) , the Inamori Foundation , and the Mitsubishi Foundation . Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = aug,
day = "20",
doi = "10.1016/j.molcel.2020.07.012",
language = "English",
volume = "79",
pages = "660--676.e8",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "4",
}