The Distinct Distributions of Immunocompetent Cells in Rat Dentin Pulp After Pulpotomy

Min Zhang, Shoichiro Kokabu, Chihiro Nakatomi, Goro Sugiyama, Kou Matsuo, Eijiro Jimi

研究成果: ジャーナルへの寄稿学術誌査読

3 被引用数 (Scopus)


Pulpotomy involves the removal of the coronal portion of pulp, including the diseased tissue, with the intent of maintaining the vitality of the remaining pulpal tissue via a therapeutic dressing. Once odontoblasts suffer injuries, the differentiation of mesenchymal cells is induced from the precursor cell population in the dental pulp, and these cells are recruited to the injured site to differentiate into odontoblasts. However, the involvement of immunocompetent cells during pulpal regeneration remains unclear. Thus, the purpose of this study was to investigate the properties of macrophages that infiltrated wound healing sites in rats between 1 and 28 days after pulpotomy (dap). During the inflammatory phase, ED1+ (CD68+) macrophages significantly increased throughout root pulp, especially apical to the demarcation zone, and this population persisted until 3 dap before decreasing gradually until 28 dap. OX6+ macrophages expressing class II MHC also increased in the apical pulp at 1 dap and declined thereafter. However, OX6+ cells appeared prior to dentin bridge formation at 3 dap and appeared again apical to the dentin bridge during the healing stage at 14 dap. The shift from ED1+ cells in the inflammation phase to OX6+ cells during dentin bridge formation might contribute to wound healing. Anat Rec, 298:741-749, 2015.

ジャーナルAnatomical Record
出版ステータス出版済み - 4月 1 2015

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 解剖学
  • 生態、進化、行動および分類学
  • 組織学


「The Distinct Distributions of Immunocompetent Cells in Rat Dentin Pulp After Pulpotomy」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。