TY - JOUR
T1 - The central corticotropin-releasing factor and glucagon-like peptide-1 in food intake of the neonatal chick
AU - Furuse, Mitsuhiro
AU - Matsumoto, Megumi
AU - Saito, Noboru
AU - Sugahara, Kunio
AU - Hasegawa, Shin
N1 - Funding Information:
This study was supported by grant-in-aid for scientific research from the Ministry of Education, Science and Culture, Japan. We are grateful to Dr. R.J. Etches, University of Guelph, Canada, for supplying the corticosterone antiserum.
PY - 1997/11/27
Y1 - 1997/11/27
N2 - Recently, we have reported that central administration of glucagon-like peptide-1 (GLP-1) strongly decreases food intake of chicks. The aim of this study was to elucidate whether suppressed food intake induced by the central injection of GLP-1 is mediated by activation of the hypothalamic-pituitary-adrenal axis. First, the effects of central administration of corticotropin-releasing factor (CRF) were investigated. Birds (2-day-old) were food-deprived for 3 h and then CRF or saline was injected intracerebroventricular (i.c.v.). CRF strongly inhibited food intake. Thereafter, effects of central CRF or GLP-1 on plasma corticosterone concentration were examined. CRF significantly stimulated corticostersne release, but GLP-1 did not alter plasma corticosterone concentration. These results suggest that CRF is a potent inhibitor of food intake in the chick, but the suppression of food intake induced by central GLP-1 may not be involved in the activation of hypothalamic-pituitary-adrenal axis.
AB - Recently, we have reported that central administration of glucagon-like peptide-1 (GLP-1) strongly decreases food intake of chicks. The aim of this study was to elucidate whether suppressed food intake induced by the central injection of GLP-1 is mediated by activation of the hypothalamic-pituitary-adrenal axis. First, the effects of central administration of corticotropin-releasing factor (CRF) were investigated. Birds (2-day-old) were food-deprived for 3 h and then CRF or saline was injected intracerebroventricular (i.c.v.). CRF strongly inhibited food intake. Thereafter, effects of central CRF or GLP-1 on plasma corticosterone concentration were examined. CRF significantly stimulated corticostersne release, but GLP-1 did not alter plasma corticosterone concentration. These results suggest that CRF is a potent inhibitor of food intake in the chick, but the suppression of food intake induced by central GLP-1 may not be involved in the activation of hypothalamic-pituitary-adrenal axis.
UR - https://www.scopus.com/pages/publications/0031588378
UR - https://www.scopus.com/pages/publications/0031588378#tab=citedBy
U2 - 10.1016/S0014-2999(97)01391-5
DO - 10.1016/S0014-2999(97)01391-5
M3 - Article
C2 - 9473137
AN - SCOPUS:0031588378
SN - 0014-2999
VL - 339
SP - 211
EP - 213
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - 2-3
ER -