TY - JOUR
T1 - The agonist action of substituted phenylethanolamines on octopamine receptors in cockroach ventral nerve cords
AU - Akinori, Hirashima
AU - Yutaka, Yoshii
AU - Morifusa, Eto
N1 - Funding Information:
Acknowledgements-We thankD r Makoto Mizunamio f theF aculty of Sciencea t KyushuU niversityfo r donating Americanc ockroache(Ps. americana). This work was supported in part by a Grant-in-Aid for ScientificR esearch from the Ministry of Education,S ciencea nd Culture of Japan.
PY - 1992/10
Y1 - 1992/10
N2 - 1. Effect of 72 ring or α-substituted phenylethanolamines (SPEAs) was examined on the adenylate cyclase prepared from ventral nerve cords of the American cockroach Periplaneta americana. 2. Para-Cl-SPEA was the most effective octopaminergic agonist, followed by p-Br-, p-F-, p-Me-, p-NO2- and p-CF3-SPEA. 3. Meta- and o-SPEAs were less active than p-SPEAs, in stimulating adenylate cyclase. 4. SPEA analogs interact with the same binding site as octopamine in the nerve cords of American cockroach, since the level of evoked cAMP production by a combination of optimally effective concentrations of octopamine and SPEA was not greater than the stimulation by octopamine alone. 5. Washing removed nearly all of the stimulatory activity of SPEA, suggesting that SPEA binds reversibly to the octopaminergic receptor.
AB - 1. Effect of 72 ring or α-substituted phenylethanolamines (SPEAs) was examined on the adenylate cyclase prepared from ventral nerve cords of the American cockroach Periplaneta americana. 2. Para-Cl-SPEA was the most effective octopaminergic agonist, followed by p-Br-, p-F-, p-Me-, p-NO2- and p-CF3-SPEA. 3. Meta- and o-SPEAs were less active than p-SPEAs, in stimulating adenylate cyclase. 4. SPEA analogs interact with the same binding site as octopamine in the nerve cords of American cockroach, since the level of evoked cAMP production by a combination of optimally effective concentrations of octopamine and SPEA was not greater than the stimulation by octopamine alone. 5. Washing removed nearly all of the stimulatory activity of SPEA, suggesting that SPEA binds reversibly to the octopaminergic receptor.
UR - https://www.scopus.com/pages/publications/0026480442
UR - https://www.scopus.com/pages/publications/0026480442#tab=citedBy
U2 - 10.1016/0742-8413(92)90015-Y
DO - 10.1016/0742-8413(92)90015-Y
M3 - Article
AN - SCOPUS:0026480442
SN - 0306-4492
VL - 103
SP - 321
EP - 325
JO - Comparative biochemistry and physiology. C: Comparative pharmacology
JF - Comparative biochemistry and physiology. C: Comparative pharmacology
IS - 2
ER -