Th subset balance in lupus nephritis

Katsuhisa Miyake, Mitsuteru Akahoshi, Hitoshi Nakashima

研究成果: ジャーナルへの寄稿総説査読

74 被引用数 (Scopus)

抄録

Lupus nephritis, which has various histological patterns and variable clinical outcomes, is one of the most important complications of systemic lupus nephritis (SLE). This pathogenetic mechanism in each histologically different type of lupus nephritis (LN) remains unclear. Although SLE is suggested to be a Th2-driven disease, elevation of both Th1 and Th2 cytokines occurs in both humans and mice, suggesting that SLE is a complex disease driven by different lymphocyte subsets with high heterogeneity of clinical manifestations and organ involvement. Recent findings in LN elucidate an essential role for the Th1, IL-17 producing T cells and Th17 cells in the development of diffuse proliferative lupus nephritis (DPLN), and Th2 cytokine in that of membranous lupus nephritis (MLN). These data support the hypothesis that individual Th1/Th2 balance is one of the critical determinants for histopathology of LN.

本文言語英語
論文番号980286
ジャーナルJournal of Biomedicine and Biotechnology
2011
DOI
出版ステータス出版済み - 2011
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 分子医療
  • 分子生物学
  • 遺伝学
  • 健康、毒物学および変異誘発

フィンガープリント

「Th subset balance in lupus nephritis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル