Ten-year national trends in in-hospital mortality and functional outcomes after intracerebral hemorrhage by age in Japan: J-ASPECT study

Yuriko Nakaoku, Soshiro Ogata, Nice Ren, Tomotaka Tanaka, Ryota Kurogi, Kunihiro Nishimura, Koji Iihara

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

Introduction: National-level data on trends in the prognosis of age-stratified patients with intracerebral hemorrhage (ICH) are lacking. This study aimed to assess time trends in in-hospital mortality and functional outcomes of ICH patients by sex and age, and to explore factors associated with changes in in-hospital mortality trend. Patients and methods: Using the largest nationwide, J-ASPECT stroke database in Japan, this serial cross-sectional study included ICH patients aged ⩾18 years who were hospitalized for non-traumatic ICH from April 2010 to March 2020. We examined trends in in-hospital mortality and functional outcomes using the modified Rankin Scale at discharge, as well as differences in in-hospital mortality change between age groups. Results: Among 262,399 ICH patients from 934 hospitals, crude in-hospital mortality showed a significant decreasing time trend (from 19.5% to 16.7%), and this trend was consistent across sex and age groups. In addition, differences in in-hospital mortality change over the 10-year study period were significant between male patients aged ⩾75 years and those aged ⩽64 years (−3.9% [95% confidence interval, −5.4 to −2.4] for 75–84 years; −4.1% [−6.3 to −1.9] for ⩾85 years). On the other hand, the proportion of dependent patients (mRS 3–5) at discharge increased from 52.0% to 54.9% over the 10-year study period. Conclusion: The in-hospital mortality of ICH patients improved, whereas the proportion of patients with dependent functional outcome at discharge increased, over the 10-year study period. Elucidating the mechanism underlying differences in in-hospital mortality reduction in men may provide insights into effective interventions in the future.

本文言語英語
ページ(範囲)398-408
ページ数11
ジャーナルEuropean Stroke Journal
9
2
DOI
出版ステータス出版済み - 6月 2024
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 臨床神経学
  • 循環器および心血管医学

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