Temperature compensation in circadian clock models

Gen Kurosawa, Yoh Iwasa

研究成果: ジャーナルへの寄稿学術誌査読

48 被引用数 (Scopus)


Circadian clock of organisms has a free-running period that does not change much with ambient temperature. This property "temperature compensation" is studied when the rate of all reaction steps increase with temperature in the biochemical network generating the rhythm. The period becomes shorter when all the rate parameters are enhanced by the same factor. However, the period becomes longer as degradation rate of proteins and/or transcription rate of the clock gene increase (their elasticity is positive). This holds for a wide range of models, including N-variable model, and PER-TIM double oscillator model, provided that (1) branch reactions (e.g. degradation of proteins or mRNAs) are strongly saturated, and that (2) the cooperativity of transcription inhibition by nuclear proteins is not very large. A strong temperature sensitivity of degradation of PER proteins and/or temperature-sensitive alternative splicing of per gene, known for Drosophila, can be mechanisms for the temperature compensation of circadian clock.

ジャーナルJournal of Theoretical Biology
出版ステータス出版済み - 4月 21 2005

!!!All Science Journal Classification (ASJC) codes

  • 統計学および確率
  • モデリングとシミュレーション
  • 生化学、遺伝学、分子生物学一般
  • 免疫学および微生物学一般
  • 農業および生物科学一般
  • 応用数学


「Temperature compensation in circadian clock models」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。