Telomerase activity detected in pancreatic juice 19 months before a tumor is detected in a patient with pancreatic cancer

Nobuhiro Suehara, Kazuhiro Mizumoto, Masahiro Kusumoto, Hideaki Niiyama, Takahiro Ogawa, Koji Yamaguchi, Kazunori Yokohata, Masao Tanaka

研究成果: ジャーナルへの寄稿学術誌査読

39 被引用数 (Scopus)

抄録

We report a patient with pancreatic cancer in whom telomerase activity had been detected in the pancreatic juice 19 months before he was diagnosed as having pancreatic cancer. A 61-yr-old alcoholic man complaining of epigastric and back pain was diagnosed as having groove pancreatitis based on the presence of inflammation in the pancreatic head and its extension to the duodenal mucosa with an associated elevated serum amylase level. All imaging modalities showed no sign of a tumor. However, high telomerase activity was detected in the pancreatic juice collected during endoscopic retrograde pancreatography. His symptoms subsided due to abstinence from alcohol. A tumor, however, was recognized on computed tomography 19 months later, at which time the patient immediately underwent a pylorus-preserving pancreaticoduodenectomy. The carcinoma was located mainly in the Santorini duct region. High telomerase activity in the pancreatic juice may precede clinical detection of pancreatic cancer and thus could be a useful early diagnostic marker for pancreatic cancer.

本文言語英語
ページ(範囲)1967-1971
ページ数5
ジャーナルAmerican Journal of Gastroenterology
93
10
DOI
出版ステータス出版済み - 10月 1998
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 肝臓学
  • 消化器病学

フィンガープリント

「Telomerase activity detected in pancreatic juice 19 months before a tumor is detected in a patient with pancreatic cancer」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル