Telomerase activation and cell proliferation during 7,12- dimethylbenz[a]anthracene-induced hamster cheek pouch carcinogenesis

Tomoki Sumida, Hiroyuki Hamakawa, Kenichi Sogawa, Yang Bao, Hirofumi Zen, Atsuro Sugita, Kenji Nezu, Yasuhito Abe, Hiroaki Tanioka, Norifumi Ueda

研究成果: ジャーナルへの寄稿学術誌査読

12 被引用数 (Scopus)

抄録

Telomerase is a ribonucleoprotein complex intimately involved in cell immortalization and carcinogenesis. This enzyme is activated and stabilizes telomere length in almost all types of cancer. Telomerase may be necessary for continuous cell proliferation. In this study, we analyzed telomerase activity in hamster experimental oral lesions (starting from epithelial hyperplasia through dysplasia, carcinoma in situ, and invasive carcinoma) evoked by 7,12-dimethylbenz[a]anthracene, and in normal mucosa. We also analyzed proliferative activity in these lesions by using immunohistochemical analysis and flow cytometry. Histologically normal epithelium expressed weak telomerase activity. The telomerase activity count increased rapidly in the early stage of carcinogenesis and gradually in the late stage. Cell- proliferative activity closely correlated with progression of disease. These findings indicate that telomerase activation is an early event and that increases in telomerase activity upregulate cell proliferation in chemically induced hamster oral carcinogenesis.

本文言語英語
ページ(範囲)164-168
ページ数5
ジャーナルMolecular Carcinogenesis
25
3
DOI
出版ステータス出版済み - 1999
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 癌研究

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