TY - JOUR
T1 - Systematic review
T2 - Sodium bicarbonate treatment regimens for the prevention of contrast-induced nephropathy
AU - Zoungas, Sophia
AU - Ninomiya, Toshiharu
AU - Huxley, Rachel
AU - Cass, Alan
AU - Jardine, Meg
AU - Gallagher, Martin
AU - Patel, Anushka
AU - Vasheghani-Farahani, Ali
AU - Sadigh, Gelareh
AU - Perkovic, Vlado
PY - 2009/11/3
Y1 - 2009/11/3
N2 - Background: Intravenous sodium bicarbonate has been proposed to reduce the risk for contrast-induced nephropathy (CIN). Purpose: To determine the effect of sodium bicarbonate on the risk for CIN. Data Sources: MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from 1950 to December 2008; conference proceedings; and ClinicalTrials.gov, without language restriction. Study Selection: Randomized, controlled trials of intravenous sodium bicarbonate that prespecified the outcome of CIN as a 25% increase in baseline serum creatinine level or an absolute increase of 44 μmol/L (0.5 mg/dL) after radiocontrast administration. Data Extraction: Using standardized protocols, 2 reviewers serially abstracted data for each study. Data Synthesis: 23 published and unpublished trials with information on 3563 patients and 396 CIN events were included. The pooled relative risk was 0.62 (95% CI, 0.45 to 0.86), with evidence of significant heterogeneity across studies (I2 = 49.1%; P = 0.004). Some heterogeneity was due to the difference in the estimates between published and unpublished studies: relative risk, 0.43 (CI, 0.25 to 0.75) versus 0.78 (CI, 0.52 to 1.17), respectively. Metaregression showed that small, poor-quality studies that assessed outcomes soon after radiocontrast administration were more likely to suggest benefit (P < 0.05 for all). No clear effects of treatment on the risk for dialysis, heart failure, and total mortality were identified. Limitation: Power to assess clinical end points was limited. Conclusion: The effectiveness of sodium bicarbonate treatment to prevent CIN in high-risk patients remains uncertain. Earlier reports probably overestimated the magnitude of any benefit, whereas larger, more recent trials have had neutral results. Large multicenter trials are required to clarify whether sodium bicarbonate has value for prevention of CIN before routine use can be recommended. Primary Funding Source: None.
AB - Background: Intravenous sodium bicarbonate has been proposed to reduce the risk for contrast-induced nephropathy (CIN). Purpose: To determine the effect of sodium bicarbonate on the risk for CIN. Data Sources: MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from 1950 to December 2008; conference proceedings; and ClinicalTrials.gov, without language restriction. Study Selection: Randomized, controlled trials of intravenous sodium bicarbonate that prespecified the outcome of CIN as a 25% increase in baseline serum creatinine level or an absolute increase of 44 μmol/L (0.5 mg/dL) after radiocontrast administration. Data Extraction: Using standardized protocols, 2 reviewers serially abstracted data for each study. Data Synthesis: 23 published and unpublished trials with information on 3563 patients and 396 CIN events were included. The pooled relative risk was 0.62 (95% CI, 0.45 to 0.86), with evidence of significant heterogeneity across studies (I2 = 49.1%; P = 0.004). Some heterogeneity was due to the difference in the estimates between published and unpublished studies: relative risk, 0.43 (CI, 0.25 to 0.75) versus 0.78 (CI, 0.52 to 1.17), respectively. Metaregression showed that small, poor-quality studies that assessed outcomes soon after radiocontrast administration were more likely to suggest benefit (P < 0.05 for all). No clear effects of treatment on the risk for dialysis, heart failure, and total mortality were identified. Limitation: Power to assess clinical end points was limited. Conclusion: The effectiveness of sodium bicarbonate treatment to prevent CIN in high-risk patients remains uncertain. Earlier reports probably overestimated the magnitude of any benefit, whereas larger, more recent trials have had neutral results. Large multicenter trials are required to clarify whether sodium bicarbonate has value for prevention of CIN before routine use can be recommended. Primary Funding Source: None.
UR - http://www.scopus.com/inward/record.url?scp=70450220298&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70450220298&partnerID=8YFLogxK
U2 - 10.7326/0003-4819-151-9-200911030-00008
DO - 10.7326/0003-4819-151-9-200911030-00008
M3 - Review article
C2 - 19884624
AN - SCOPUS:70450220298
SN - 0003-4819
VL - 151
SP - 631
EP - 638
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
IS - 9
ER -