Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature

Mamiko Asano, Kazuo Harada, Tomoaki Yoshikawa, Takeshi Bamba, Kazumasa Hirata

研究成果: ジャーナルへの寄稿学術誌査読

8 被引用数 (Scopus)

抄録

We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near- ultraviolet light at 4 °C. It indicates that this coupling reaction at 4 °C occurs non-enzymatically.

本文言語英語
ページ(範囲)386-389
ページ数4
ジャーナルBioscience, Biotechnology and Biochemistry
74
2
DOI
出版ステータス出版済み - 2010
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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