@article{ee207b7c3b774f45a72e7eb7bd7b914d,
title = "Synthesis of 28-19F-amphotericin B methyl ester",
abstract = "A fluorinated amphotericin B (AmB) derivative, 28-19F-AmB methyl ester (3), labeled at the polyene moiety, was synthesized by combining chemical synthesis with degradation of a natural product via cross-coupling reactions and macrolactonization. The fluorinated derivative 3 showed antifungal activity similar to that of AmB, and is expected to be a powerful tool for NMR-based investigation of the mechanism of ion-channel formation.",
author = "Hiroshi Tsuchikawa and Naohiro Matsushita and Nobuaki Matsumori and Michio Murata and Tohru Oishi",
note = "Funding Information: We are grateful to Professor Yasuhiro Uozumi and Dr. Hiroaki Sasagawa of the Institute for Molecular Science for measurement of 920 MHz 1 H NMR spectra. This work was supported by Grants-In-Aid for Scientific Research (Nos. 15201048 and 15350024), for Scientific Research in Priority Areas (A) (Nos. 12045243 and 16073211), and for Young Scientists (A) (No. 17681027) from MEXT, Japan. ",
year = "2006",
month = aug,
day = "28",
doi = "10.1016/j.tetlet.2006.06.159",
language = "English",
volume = "47",
pages = "6187--6191",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "35",
}