Synthesis and properties of N-t-butylaminoxyl nucleosides.

Toshiyuki Kaneko; Mariko Aso; Morihide Nakamura; Yasuhiro Matsui; Noboru Koga; Hiroshi Suemune

doi:10.1093/nass/2.1.139

Synthesis and properties of N-t-butylaminoxyl nucleosides.

Toshiyuki Kaneko
, Mariko Aso
, Morihide Nakamura
, Yasuhiro Matsui
, Noboru Koga
, Hiroshi Suemune

医薬化学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

抄録

Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.

本文言語	英語
ページ（範囲）	139-140
ページ数	2
ジャーナル	Nucleic acids research. Supplement (2001)
号	2
DOI	https://doi.org/10.1093/nass/2.1.139
出版ステータス	出版済み - 2002

!!!All Science Journal Classification (ASJC) codes

医学一般

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10.1093/nass/2.1.139

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abstract = "Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.",

author = "Toshiyuki Kaneko and Mariko Aso and Morihide Nakamura and Yasuhiro Matsui and Noboru Koga and Hiroshi Suemune",

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AU - Nakamura, Morihide

AU - Matsui, Yasuhiro

AU - Koga, Noboru

AU - Suemune, Hiroshi

PY - 2002

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AB - Novel purine nucleosides with a N-tert-butylhydroxylamino group at the 2-position of purine nucleus (1-3) were synthesized, which might prefer anti conformation and would not perturb DNA structure when incorporated into oligonucleotide. Oxidation of 1-3 by treatment with Ag2O or air afforded stable aminoxyl radicals (1'-3') and their properties were studied by EPR spectroscopy. 5-N-tert-butylhydroxylamino uridine (4) was also synthesized.

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Synthesis and properties of N-t-butylaminoxyl nucleosides.

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