Synthesis and properties of a new class of nucleosides with spin source.

M. Aso, T. Ikeno, T. Kaneko, N. Koga, H. Suemune

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

Novel spin-labeled ribonucleosides 1-5 were synthesized to investigate stability and behavior of N-tert-butyl aminoxyl radical on nucleobase. Site selective lithiation of tri-O-protected ribonucleosides followed by the reaction with 2-methyl-2-nitrosopropane (MNP) resulted in introduction of N-tert-butylhydroxylamino group into various positions of purine or pyrimidine nucleus. Oxidation of the obtained hydroxylamines with Ag2O led to formation of 1-5. EPR study showed that the unpaired electron of the aminoxyl radical was delocalized into the nucleobase and hyperfine structures were dependent on the position of the radical.

本文言語英語
ページ(範囲)115-116
ページ数2
ジャーナルNucleic acids research. Supplement (2001)
1
出版ステータス出版済み - 2001

!!!All Science Journal Classification (ASJC) codes

  • 医学一般

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