Synthesis and evaluation of oligonucleotides incorporating novel artificial nucleobases for the selective formation of non-natural type triplexes.

S. Nakashima, N. Matsuura, F. Nagatsugi, M. Maeda, S. Sasaki

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

Regulation of specific gene expression by the sequence specific triplex formation has been expected as a new biological tool or a new therapeutic method in the so-called antigene strategy. As native nucleobases form triplexes only within homopurine-homopyrimidine duplexes, expansion of the target sequences to general ones has been desired. We have previously reported the selective formation of base triplets by the non-native nucleobases (1, 2) with a CG or a TA base pair, respectively, in the organic solvent. In this paper, we wish to report the synthesis of the new non-native bases (3, 4, 9-11) and their incorporation into the triplex-forming oligonucleotides (TFOs), as well as their ability of triplex formation.

本文言語英語
ページ(範囲)33-34
ページ数2
ジャーナルNucleic acids symposium series
37
出版ステータス出版済み - 1997

!!!All Science Journal Classification (ASJC) codes

  • 医学一般

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