TY - JOUR
T1 - Synthesis and bio-applications of carbohydrate-gold nanoconjugates with nanoparticle and nanolayer forms
AU - Kitaoka, Takuya
AU - Yokota, Shingo
AU - Opietnik, Martina
AU - Rosenau, Thomas
N1 - Funding Information:
The studies in this review article were supported by a Research Fellowship for Young Scientists from the Japan Society for the Promotion of Science (S.Y.) , by a Grant-in-Aid for Young Scientists (S: 21678002 ) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (T.K.) , and by the Austrian Christian Doppler Society (T.R.) .
PY - 2011/8/12
Y1 - 2011/8/12
N2 - Carbohydrate-conjugated gold nanoparticles (GNPs) and gold nanolayers (GNLs), which have recently attracted increasing attention as innovative nano-biomaterials, were successfully synthesized using carbohydrate thiosemicarbazones in an aqueous N-methylmorpholine N-oxide (NMMO) system. This system can dissolve various types of carbohydrates including structural polysaccharides, e.g., cellulose. We observed that oxidative NMMO solvent unexpectedly promoted the immediate reduction of [AuIIICl 4]- species to nanosized metallic Au0, that is GNP. One possible mechanism is that the chloride ligand was oxidized to chlorate via the formation of a hypochlorite intermediate. Site-selective S-labeling of sugar reducing ends with thiosemicarbazide may have enabled regulated self-assembly immobilization to the surfaces of GNPs and GNLs. The carbohydrate-gold nanoconjugates possess unique nanoarchitectures and biofunctions for carbohydrate-cell interactions. Novel and simple approaches for the structural design of carbohydrate-decorated GNPs and GNLs in the NMMO system have potential to inspire a new phase in glyco-biomaterials engineering.
AB - Carbohydrate-conjugated gold nanoparticles (GNPs) and gold nanolayers (GNLs), which have recently attracted increasing attention as innovative nano-biomaterials, were successfully synthesized using carbohydrate thiosemicarbazones in an aqueous N-methylmorpholine N-oxide (NMMO) system. This system can dissolve various types of carbohydrates including structural polysaccharides, e.g., cellulose. We observed that oxidative NMMO solvent unexpectedly promoted the immediate reduction of [AuIIICl 4]- species to nanosized metallic Au0, that is GNP. One possible mechanism is that the chloride ligand was oxidized to chlorate via the formation of a hypochlorite intermediate. Site-selective S-labeling of sugar reducing ends with thiosemicarbazide may have enabled regulated self-assembly immobilization to the surfaces of GNPs and GNLs. The carbohydrate-gold nanoconjugates possess unique nanoarchitectures and biofunctions for carbohydrate-cell interactions. Novel and simple approaches for the structural design of carbohydrate-decorated GNPs and GNLs in the NMMO system have potential to inspire a new phase in glyco-biomaterials engineering.
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U2 - 10.1016/j.msec.2010.10.009
DO - 10.1016/j.msec.2010.10.009
M3 - Article
AN - SCOPUS:79957795465
SN - 0928-4931
VL - 31
SP - 1221
EP - 1229
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
IS - 6
ER -