Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

Hisashi Shimakoshi; Takeshi Kaieda; Takashi Matsuo; Hideaki Sato; Yoshio Hisaeda

doi:10.1016/S0040-4039(03)01252-8

Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

Hisashi Shimakoshi
, Takeshi Kaieda
, Takashi Matsuo
, Hideaki Sato
, Yoshio Hisaeda

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

36 被引用数 (Scopus)

抄録

One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by ¹H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.

本文言語	英語
ページ（範囲）	5197-5199
ページ数	3
ジャーナル	Tetrahedron Letters
巻	44
号	28
DOI	https://doi.org/10.1016/S0040-4039(03)01252-8
出版ステータス	出版済み - 7月 7 2003

!!!All Science Journal Classification (ASJC) codes

生化学
創薬
有機化学

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10.1016/S0040-4039(03)01252-8

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title = "Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage",

abstract = "One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by 1H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.",

author = "Hisashi Shimakoshi and Takeshi Kaieda and Takashi Matsuo and Hideaki Sato and Yoshio Hisaeda",

note = "Funding Information: We thank Professor T. Hayashi (Kyushu University) for useful discussions and Professor S. Takenaka and Dr. K. Yamashita (Kyushu University) for help with gel-electrophoretic analyses. This work was partially supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.",

year = "2003",

month = jul,

day = "7",

doi = "10.1016/S0040-4039(03)01252-8",

language = "English",

volume = "44",

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journal = "Tetrahedron Letters",

issn = "0040-4039",

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TY - JOUR

T1 - Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

AU - Shimakoshi, Hisashi

AU - Kaieda, Takeshi

AU - Matsuo, Takashi

AU - Sato, Hideaki

AU - Hisaeda, Yoshio

N1 - Funding Information: We thank Professor T. Hayashi (Kyushu University) for useful discussions and Professor S. Takenaka and Dr. K. Yamashita (Kyushu University) for help with gel-electrophoretic analyses. This work was partially supported by Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

PY - 2003/7/7

Y1 - 2003/7/7

N2 - One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by 1H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.

AB - One-pot syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds are reported. The complexes were characterized by 1H NMR and UV-vis spectroscopies as well as ESI-MS. These complexes were photosensitive, and photo-cleavage of the cobalt-carbon bonds upon irradiation with visible light produced methyl radicals which were detected by ESR spin-trapping techniques. The dicobalt complexes exhibited high ability for DNA cleavage in comparison with that for the corresponding monocobalt complex.

UR - https://www.scopus.com/pages/publications/0038684458

UR - https://www.scopus.com/pages/publications/0038684458#tab=citedBy

U2 - 10.1016/S0040-4039(03)01252-8

DO - 10.1016/S0040-4039(03)01252-8

M3 - Article

AN - SCOPUS:0038684458

SN - 0040-4039

VL - 44

SP - 5197

EP - 5199

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 28

ER -

Syntheses of new water-soluble dicobalt complexes having two cobalt-carbon bonds and their ability for DNA cleavage

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!!!All Science Journal Classification (ASJC) codes

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