Surf4 modulates STIM1-dependent calcium entry

Yoko Fujii; Masayuki Shiota; Yasuyuki Ohkawa; Akemi Baba; Hideki Wanibuchi; Tatsuo Kinashi; Tomohiro Kurosaki; Yoshihiro Baba

doi:10.1016/j.bbrc.2012.05.037

Surf4 modulates STIM1-dependent calcium entry

Yoko Fujii
, Masayuki Shiota
, Yasuyuki Ohkawa
, Akemi Baba
, Hideki Wanibuchi
, Tatsuo Kinashi
, Tomohiro Kurosaki
, Yoshihiro Baba

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

38 被引用数 (Scopus)

抄録

Store-operated Ca ²⁺ entry (SOCE) is crucial for various physiological responses in immune cells. Although it is known that STIM1 relocates into discrete puncta juxtaposed to the plasma membrane to initiate SOCE, the machinery modulating the function of STIM1 remains unclear. We explored to find its modulators using affinity purification for STIM1-binding proteins and identified surfeit locus protein 4 (Surf4). Surf4 associated with STIM1 in the endoplasmic reticulum. Deletion of Surf4 in DT40 B cells resulted in marked increase of SOCE and facilitation of STIM1 clustering upon store-depletion. These findings suggest the modulatory function of Surf4 for STIM1-mediated SOCE.

本文言語	英語
ページ（範囲）	615-620
ページ数	6
ジャーナル	Biochemical and Biophysical Research Communications
巻	422
号	4
DOI	https://doi.org/10.1016/j.bbrc.2012.05.037
出版ステータス	出版済み - 6月 15 2012

!!!All Science Journal Classification (ASJC) codes

生物理学
生化学
分子生物学
細胞生物学

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10.1016/j.bbrc.2012.05.037

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title = "Surf4 modulates STIM1-dependent calcium entry",

abstract = "Store-operated Ca 2+ entry (SOCE) is crucial for various physiological responses in immune cells. Although it is known that STIM1 relocates into discrete puncta juxtaposed to the plasma membrane to initiate SOCE, the machinery modulating the function of STIM1 remains unclear. We explored to find its modulators using affinity purification for STIM1-binding proteins and identified surfeit locus protein 4 (Surf4). Surf4 associated with STIM1 in the endoplasmic reticulum. Deletion of Surf4 in DT40 B cells resulted in marked increase of SOCE and facilitation of STIM1 clustering upon store-depletion. These findings suggest the modulatory function of Surf4 for STIM1-mediated SOCE.",

keywords = "STIM1, Store-operated calcium entry, Surf4",

author = "Yoko Fujii and Masayuki Shiota and Yasuyuki Ohkawa and Akemi Baba and Hideki Wanibuchi and Tatsuo Kinashi and Tomohiro Kurosaki and Yoshihiro Baba",

note = "Funding Information: We thank R. Tsien (University of California at San Diego) for providing the pRSETB-mCherry plasmid. We are thankful to M. Matsumoto for critical reading of the manuscript. This work was supported by Grant-in-Aids for the Ministry of Education, Culture, Sports, Science and Technology, Japan (Y.B. and T.K.) and for Japan Science and Technology Agency and Core Research for Evolutional Science and Technology (T.K.) and “HISHO” The Top Thirty Young Researchers of Osaka University (Y.B.).",

year = "2012",

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doi = "10.1016/j.bbrc.2012.05.037",

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TY - JOUR

T1 - Surf4 modulates STIM1-dependent calcium entry

AU - Fujii, Yoko

AU - Shiota, Masayuki

AU - Ohkawa, Yasuyuki

AU - Baba, Akemi

AU - Wanibuchi, Hideki

AU - Kinashi, Tatsuo

AU - Kurosaki, Tomohiro

AU - Baba, Yoshihiro

N1 - Funding Information: We thank R. Tsien (University of California at San Diego) for providing the pRSETB-mCherry plasmid. We are thankful to M. Matsumoto for critical reading of the manuscript. This work was supported by Grant-in-Aids for the Ministry of Education, Culture, Sports, Science and Technology, Japan (Y.B. and T.K.) and for Japan Science and Technology Agency and Core Research for Evolutional Science and Technology (T.K.) and “HISHO” The Top Thirty Young Researchers of Osaka University (Y.B.).

PY - 2012/6/15

Y1 - 2012/6/15

N2 - Store-operated Ca 2+ entry (SOCE) is crucial for various physiological responses in immune cells. Although it is known that STIM1 relocates into discrete puncta juxtaposed to the plasma membrane to initiate SOCE, the machinery modulating the function of STIM1 remains unclear. We explored to find its modulators using affinity purification for STIM1-binding proteins and identified surfeit locus protein 4 (Surf4). Surf4 associated with STIM1 in the endoplasmic reticulum. Deletion of Surf4 in DT40 B cells resulted in marked increase of SOCE and facilitation of STIM1 clustering upon store-depletion. These findings suggest the modulatory function of Surf4 for STIM1-mediated SOCE.

AB - Store-operated Ca 2+ entry (SOCE) is crucial for various physiological responses in immune cells. Although it is known that STIM1 relocates into discrete puncta juxtaposed to the plasma membrane to initiate SOCE, the machinery modulating the function of STIM1 remains unclear. We explored to find its modulators using affinity purification for STIM1-binding proteins and identified surfeit locus protein 4 (Surf4). Surf4 associated with STIM1 in the endoplasmic reticulum. Deletion of Surf4 in DT40 B cells resulted in marked increase of SOCE and facilitation of STIM1 clustering upon store-depletion. These findings suggest the modulatory function of Surf4 for STIM1-mediated SOCE.

KW - STIM1

KW - Store-operated calcium entry

KW - Surf4

UR - https://www.scopus.com/pages/publications/84862272823

UR - https://www.scopus.com/pages/publications/84862272823#tab=citedBy

U2 - 10.1016/j.bbrc.2012.05.037

DO - 10.1016/j.bbrc.2012.05.037

M3 - Article

C2 - 22609200

AN - SCOPUS:84862272823

SN - 0006-291X

VL - 422

SP - 615

EP - 620

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Surf4 modulates STIM1-dependent calcium entry

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