Successful foscarnet therapy for mucocutaneous infection with herpes simplex virus in a recipient after unrelated bone marrow transplantation

T. Iino, H. Gondo, Y. Ohno, H. Minagawa, H. Iwasaki, T. Maruyama, H. Nakashima, Y. Niho

    研究成果: ジャーナルへの寄稿学術誌査読

    11 被引用数 (Scopus)

    抄録

    A 36-year-old Japanese man who received an unrelated bone marrow transplant (BMT) developed severe mucocutaneous infection with herpes simplex virus (HSV) type 1 during oral acyclovir prophylaxis. The lesions progressed despite treatment with intravenous acyclovir and vidarabine. The HSV isolates were sensitive to acyclovir, vidarabine and foscarnet in vitro, but peripheral CD3- or CD19-positive cells were barely detectable even 4 months after transplant. A 12-day course of treatment with foscarnet led to a rapid improvement. Foscarnet therapy should be considered for all severe HSV infections following BMT, regardless of whether or not the HSV isolates are sensitive to acyclovir.

    本文言語英語
    ページ(範囲)1185-1188
    ページ数4
    ジャーナルBone Marrow Transplantation
    18
    6
    出版ステータス出版済み - 12月 1996

    !!!All Science Journal Classification (ASJC) codes

    • 血液学
    • 移植

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