TY - JOUR
T1 - Structures of the Largest Amphidinol Homologues from the Dinoflagellate Amphidinium carterae and Structure-Activity Relationships
AU - Satake, Masayuki
AU - Cornelio, Kimberly
AU - Hanashima, Shinya
AU - Malabed, Raymond
AU - Murata, Michio
AU - Matsumori, Nobuaki
AU - Zhang, Huiping
AU - Hayashi, Fumiaki
AU - Mori, Shoko
AU - Kim, Jong Souk
AU - Kim, Chang Hoon
AU - Lee, Jong Soo
N1 - Funding Information:
This work was partly supported by Scientific Research KAKENHIs (S), (A), and (C) with Grant Nos. 16H06315, 25242073, and15K01798, respectively, and also by Korea Institute of Marine Science & Technology Promotion (Project No. D11111112H390000140).
Publisher Copyright:
© 2017 The American Chemical Society and American Society of Pharmacognosy.
PY - 2017/11/22
Y1 - 2017/11/22
N2 - Amphidinols are polyketide metabolites produced by marine dinoflagellates and are chiefly composed of a long linear chain with polyol groups and polyolefins. Two new homologues, amphidinols 20 (AM20, 1) and 21 (AM21, 2), were isolated from Amphidinium carterae collected in Korea. Their structures were elucidated by detailed NMR analyses as amphidinol 6-type compounds with remarkably long polyol chains. Amphidinol 21 (2) has the longest linear structure among the amphidinol homologues reported so far. The congeners, particularly amphidinol 21 (2), showed weaker activity in hemolysis and antifungal assays compared to known amphidinols.
AB - Amphidinols are polyketide metabolites produced by marine dinoflagellates and are chiefly composed of a long linear chain with polyol groups and polyolefins. Two new homologues, amphidinols 20 (AM20, 1) and 21 (AM21, 2), were isolated from Amphidinium carterae collected in Korea. Their structures were elucidated by detailed NMR analyses as amphidinol 6-type compounds with remarkably long polyol chains. Amphidinol 21 (2) has the longest linear structure among the amphidinol homologues reported so far. The congeners, particularly amphidinol 21 (2), showed weaker activity in hemolysis and antifungal assays compared to known amphidinols.
UR - http://www.scopus.com/inward/record.url?scp=85034963714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85034963714&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.7b00345
DO - 10.1021/acs.jnatprod.7b00345
M3 - Article
C2 - 29120640
AN - SCOPUS:85034963714
SN - 0163-3864
VL - 80
SP - 2883
EP - 2888
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 11
ER -
