Stress amelioration and anti-inflammatory potential of Shiikuwasha (Citrus depressa Hayata) essential oil, limonene, and γ-terpinene

Yonathan Asikin, Kuniyoshi Shimizu, Hironori Iwasaki, Hirosuke Oku, Koji Wada

研究成果: ジャーナルへの寄稿学術誌査読

5 被引用数 (Scopus)

抄録

Shiikuwasha (Citrus depressa Hayata) essential oil (SEO) extracted from Shiikuwasha fruit pulp contains two major volatile components, limonene and g-terpinene (56.56e57.31 and 24.41e24.98%, respectively). In this study, we showed that the aroma streams of SEO, limonene, and g-terpinene exhibited significant physiological stress amelioration effects in nine healthy female panelists tested in a 30-min visual display task. While SEO administration significantly reduced work errors by 15 min compared to the odorless control condition, the limonene stream reduced work errors only at the first and fourth 5-min intervals, and the g-terpinene effect lasted only for the initial 5-min. However, g-terpinene inhalation reduced stress by significantly increasing post-work electrocardiogram ReR interval variability and lowering electroencephalogram beta wave powers at the midline occipital Oz position. Additionally, SEO, limonene, and g-terpinene displayed anti-inflammatory activity in vitro by suppressing the pro-inflammatory markers NO and IL-1b in BV- 2 microglial cells in a dose-dependent manner.

本文言語英語
論文番号10
ページ(範囲)454-465
ページ数12
ジャーナルJournal of Food and Drug Analysis
30
3
DOI
出版ステータス出版済み - 2022

!!!All Science Journal Classification (ASJC) codes

  • 食品科学
  • 薬理学

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