Steroidal saponins from dioscorea preussii

Turibio Kuiate Tabopda, Anne Claire Mitaine-Offer, Chiaki Tanaka, Tomofumi Miyamoto, Jean François Mirjolet, Olivier Duchamp, Bonaventure Tchaleu Ngadjui, Marie Aleth Lacaille-Dubois

研究成果: ジャーナルへの寄稿学術誌査読

16 被引用数 (Scopus)

抄録

Three new steroidal saponins, named diospreussinosides A-C (1-3), along with two known ones (4, 5) were isolated from rhizomes of Dioscorea preussii. Their structures were elucidated mainly by 1D and 2D NMR spectroscopic analysis and mass spectrometry as (25S)-17α,25-dihydroxyspirost-5-en-3β-yl-O- α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-β-d-glucopyranoside (1), (25S)-17α,25-dihydroxyspirost-5-en- 3β-yl-O-α-l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-[α-l-rhamnopyranosyl-(1 → 2)]-β-d-glucopyranoside (2), and (24S,25R)-17α,24,25-trihydroxyspirost-5-en-3β-yl-O-α- l-rhamnopyranosyl-(1 → 4)-α-l-rhamnopyranosyl-(1 → 4)-[α-l-rhamnopyranosyl-(1 → 2)]-β-d-glucopyranoside (3). The spirostane-type skeleton of compound 3 possessing an unusual dihydroxylation pattern on the F-ring is reported for the first time. Cytotoxicity of compounds 2-5 was evaluated against two human colon carcinoma cell lines (HT-29 and HCT 116).

本文言語英語
ページ(範囲)198-203
ページ数6
ジャーナルFitoterapia
97
DOI
出版ステータス出版済み - 9月 2014

!!!All Science Journal Classification (ASJC) codes

  • 薬理学
  • 創薬

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