Steroid 5α-reductase inhibitory activity of condensed tannins from woody plants

Jie Liu, Ryo Ando, Kuniyoshi Shimizu, Koh Hashida, Rei Makino, Seiji Ohara, Ryuichiro Kondo

研究成果: ジャーナルへの寄稿学術誌査読

17 被引用数 (Scopus)

抄録

In humans, steroid 5α-reductase is involved in the development of benign prostatic hyperplasia (BPH). We tested the steroid 5α-reductase inhibitory activity of the 70% acetone extract of woody plants. The tannin polymer prepared from the 70% acetone extract showed the highest steroid 5α-reductase inhibitory activity. Furthermore, the steroid 5α-reductase inhibitory activity of tannins was not affected by the addition of superoxide dismutase or catalase. It was concluded that the steroid 5α-reductase inhibitory activity of condensed tannin was caused by binding to the steroid 5α-reductase, rather than from the peroxide/superoxide produced by tannins. The tannins, prepared from tree barks, with potential for steroid 5α-reductase inhibitory activity might be advantageous in therapy for steroid 5α-reductase diseases such as BPH or prostate cancer.

本文言語英語
ページ(範囲)68-75
ページ数8
ジャーナルJournal of Wood Science
54
1
DOI
出版ステータス出版済み - 1月 2008

!!!All Science Journal Classification (ASJC) codes

  • 生体材料

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