Stereospecificity of hydroxyl group at C-20 in antiproliferative action of ginsenoside Rh2 on prostate cancer cells

Jie Liu, Kuniyoshi Shimizu, Hongshan Yu, Chunzhi Zhang, Fengxie Jin, Ryuichiro Kondo

研究成果: ジャーナルへの寄稿学術誌査読

56 被引用数 (Scopus)

抄録

Prostate cancer is the fifth most common neoplasm worldwide, and the second most common cancer among men. Ginsenosides, the main component of ginseng, have been known for their medicinal effects such as anti-inflammatory and anti-proliferative activities. In this study, we investigated the inhibitory effects of ginsenosides (ginsenoside 20(R)-Rh2 and ginsenoside 20(S)-Rh2) on prostate cancer cells in vitro. Only ginsenoside 20(S)-Rh2 showed proliferation inhibition on androgen-dependent and -independent prostate cancer cells. These results implied that the stereochemistry of the hydroxyl group at C-20 may play an important role in antitumor activities.

本文言語英語
ページ(範囲)902-905
ページ数4
ジャーナルFitoterapia
81
7
DOI
出版ステータス出版済み - 10月 2010

!!!All Science Journal Classification (ASJC) codes

  • 薬理学
  • 創薬

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