Spontaneous splenic rupture in a patient with light-chain deposition disease undergoing autologous peripheral blood stem cell transplantation

Shojiro Haji, Junichi Kiyasu, Yoshimichi Tachikawa, Jiro Toyonaga, Motohiko Ikeda, Mariko Tsuda, Yasuhiro Tsukamoto, Mitsuo Kozuru, Yuji Yufu

研究成果: ジャーナルへの寄稿学術誌査読

2 被引用数 (Scopus)

抄録

Light-chain deposition disease (LCDD) is a rare plasma cell neoplasm that secretes an abnormal immunoglobulin light chain, which is deposited in tissues, leading to organ dysfunction. Spontaneous splenic rupture is a rare and life-threatening complication of treatment with granulocyte colony-stimulating factor (G-CSF). Herein, we describe spontaneous splenic rupture after the administration of lenograstim to a patient with LCDD undergoing autologous stem cell transplantation (ASCT). The patient was successfully treated by transcatheter embolization of the splenic artery, and long-term stringent complete remission was attained. Plasma cell neoplasms, including multiple myeloma with amyloidosis, are among the most commonly reported conditions associated with spontaneous splenic rupture in patients undergoing ASCT. This finding suggests that, in addition to the effect of G-CSF on the spleen, a combination of factors, including tissue vulnerability induced by the infiltration of abnormal immunoglobulins, may be involved in the pathogenesis of spontaneous splenic rupture. Notably, splenomegaly is not always evident in these patients. Surgical treatment may not be an option, because of severe myelosuppression, and thus less invasive treatment using transcatheter embolization may be feasible.

本文言語英語
ページ(範囲)754-759
ページ数6
ジャーナル[Rinsho ketsueki] The Japanese journal of clinical hematology
57
6
DOI
出版ステータス出版済み - 6月 1 2016
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 医学一般

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