Solution structures of a monodentate chiral lithium amide in the presence of lithium halide

Keizo Sugasawa; Mitsuru Shindo; Hiroshi Noguchi; Kenji Koga

doi:10.1016/0040-4039(96)01681-4

Solution structures of a monodentate chiral lithium amide in the presence of lithium halide

Keizo Sugasawa, Mitsuru Shindo, Hiroshi Noguchi, Kenji Koga

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

68 被引用数 (Scopus)

抄録

Enantioselectivity of deprotonation reaction of 4-tert-butylcyclohexanone (2) by a monodentate chiral lithium amide ((R,R)-1) in THF is strongly influenced by the presence of lithium halides. Aggregation states of this chiral lithium amide in THF-d₈ in the absence and in the presence of lithium halides were studied by ⁶Li and ¹⁵N NMR. It is concluded that the mixed dimer (D) is the species to give the high enantioselectivity of the reaction.

本文言語	英語
ページ（範囲）	7377-7380
ページ数	4
ジャーナル	Tetrahedron Letters
巻	37
号	41
DOI	https://doi.org/10.1016/0040-4039(96)01681-4
出版ステータス	出版済み - 10月 7 1996
外部発表	はい

!!!All Science Journal Classification (ASJC) codes

生化学
創薬
有機化学

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10.1016/0040-4039(96)01681-4

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title = "Solution structures of a monodentate chiral lithium amide in the presence of lithium halide",

abstract = "Enantioselectivity of deprotonation reaction of 4-tert-butylcyclohexanone (2) by a monodentate chiral lithium amide ((R,R)-1) in THF is strongly influenced by the presence of lithium halides. Aggregation states of this chiral lithium amide in THF-d8 in the absence and in the presence of lithium halides were studied by 6Li and 15N NMR. It is concluded that the mixed dimer (D) is the species to give the high enantioselectivity of the reaction.",

author = "Keizo Sugasawa and Mitsuru Shindo and Hiroshi Noguchi and Kenji Koga",

year = "1996",

month = oct,

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doi = "10.1016/0040-4039(96)01681-4",

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journal = "Tetrahedron Letters",

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T1 - Solution structures of a monodentate chiral lithium amide in the presence of lithium halide

AU - Sugasawa, Keizo

AU - Shindo, Mitsuru

AU - Noguchi, Hiroshi

AU - Koga, Kenji

PY - 1996/10/7

Y1 - 1996/10/7

N2 - Enantioselectivity of deprotonation reaction of 4-tert-butylcyclohexanone (2) by a monodentate chiral lithium amide ((R,R)-1) in THF is strongly influenced by the presence of lithium halides. Aggregation states of this chiral lithium amide in THF-d8 in the absence and in the presence of lithium halides were studied by 6Li and 15N NMR. It is concluded that the mixed dimer (D) is the species to give the high enantioselectivity of the reaction.

AB - Enantioselectivity of deprotonation reaction of 4-tert-butylcyclohexanone (2) by a monodentate chiral lithium amide ((R,R)-1) in THF is strongly influenced by the presence of lithium halides. Aggregation states of this chiral lithium amide in THF-d8 in the absence and in the presence of lithium halides were studied by 6Li and 15N NMR. It is concluded that the mixed dimer (D) is the species to give the high enantioselectivity of the reaction.

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U2 - 10.1016/0040-4039(96)01681-4

DO - 10.1016/0040-4039(96)01681-4

M3 - Article

AN - SCOPUS:0030574042

SN - 0040-4039

VL - 37

SP - 7377

EP - 7380

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 41

ER -

Solution structures of a monodentate chiral lithium amide in the presence of lithium halide

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!!!All Science Journal Classification (ASJC) codes

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