Small intestinal transplantation in the rat: Effect on physiological properties of smooth muscle and nerves

T. Taguchi, E. Zorychta, R. E. Sonnino, F. M. Guttman

研究成果: ジャーナルへの寄稿学術誌査読

26 被引用数 (Scopus)

抄録

The effect of transplantation on the physiological and pharmacologic properties of small intestine was evaluated in a syngeneic rat model. We examined the intrinsic contractile properties of the smooth muscle, the neural control of intestinal motility, and the sensitivity of the muscle and nerve endings to biologically active compounds in vitro, comparing transplanted tissue to controls. Both graft and control tissue contracted in a dose-dependent manner to cholinergic agonists, 5-hydroxytryptamine, and substance P and relaxed in response to noradrenaline. Contractile properties of smooth muscle and sensitivity to drugs were not altered by transplantation. Excitatory innervation was also similar in all specimens, but the inhibitory response was altered by transplantation. In the control intestine inhibition became maximal above 30 Hz, while in the graft maximal inhibition was obtained at 5 Hz. These findings imply an absence of extrinsic adrenergic inhibitory innervation in the graft. Intrinsic nonadrenergic inhibitory nerves and the excitatory innervation were intact after transplantation.

本文言語英語
ページ(範囲)1258-1263
ページ数6
ジャーナルJournal of Pediatric Surgery
24
12
DOI
出版ステータス出版済み - 12月 1989
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 外科
  • 小児科学、周産期医学および子どもの健康

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